THE ULTIMATE GUIDE TO PKRRATING

The activated enzyme then phosphorylates its key substrate, the translational initiation element eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs into a conserved relatives of four protein kinases (PKR, PERK, GCN2, HRI) that every one phosphorylate eIF2α in reaction to various stimuli12, triggering the integrated worr